HIV-1 Gag Gene – Understanding Current Trends in the Developmentof Promising ARV Treatments
août 31, 2026Brief communication: virological response anddrug resistance patterns among men who havesex with men in Yaoundé-Cameroon
août 31, 2026Michel Carlos Tommo Tchouaket1, at all
Abstract
Background Cameroon lacks a national screening algorithm for Human papilloma virus (HPV) infection. In order to standardize HPV screening using molecular detection tools in Cameroon, this study aimed to evaluate the concordance of HPV detection via two multiplex systems and profile the epidemiology of High-risk oncogenic HPV (HR-HPV) circulating locally.
Methods A cross-sectional study was conducted on endocervical samples collected among women in Cameroon. HR-HPV detection and genotyping was done using Abbott and Sacace kits simultaneously. Discordant results were retested using Anyplex II HPV28 kit.
Results Of 364 participants enrolled (median-age: 42 [IQR:34–50] years), overall HR-HPV positivity was 21.4% (78/364) versus 15.4% (56/364) using Abbott and Sacace, respectively. Detection concordance between the test kits was strong (kappa-value = 0.8). Of 22 samples with discordant results, 86.36% (19/22) were further confirmed with Anyplex II HPV28; yielding an overall HR-HPV positivity prevalence of 20.6% (75/364), with 12 genotypes circulating. The most